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29. "Unimolecular net heterolysis of symmetric and homopolar σ-bonds"

Anna F. Tiefel, Daniel J. Grenda, Carina Allacher, Elias Harrer, Carolin H. Nagel, Roger J. Kutta, David Hernández-Castillo, Poorva R. Narasimhamurthy, Kirsten Zeitler, Leticia González, Julia Rehbein, Patrick Nuernberger, Alexander Breder, Nature 2024 (accepted manuscript)


28. "Intermolecular Aza-Wacker Coupling of Alkenes with Azoles by Photo-Aerobic Selenium-π-Acid Multicatalysis"

Tao Lei, Theresa Appleson, Alexander Breder,* ACS Catal. 2024, 14, 95869593. (†these authors contributed equally)



27. "Mechanistic Analysis Reveals Key Role of Interchalcogen Multicatalysis in Photo-Aerobic 3-Pyrroline Syntheses by Aza-Wacker Cyclizations"

Sebastian Graf, Henner Pesch, Theresa Appleson, Tao Lei, Alexander Breder,* Inke Siewert,* ChemSusChem 2024, e202301518 (manuscript accepted, †these authors contributed equally)




26. "Asymmetric Photo-Aerobic Lactonization and aza-Wacker Cyclization of Alkenes Enabled by Ternary Selenium-Sulfur Multicatalysis"

Tao Lei, Sebastian Graf, Christopher Schöll, Felix Krätzschmar, Bernhard Gregori, Theresa Appleson, Alexander Breder*, ACS Catal. 2023, 13, 1624016248 (†these authors contributed equally) (https://pubs.acs.org/doi/10.1021/acscatal.3c04443)





25. "Synthesis of 1,3-Dioxan-2-ones by Photo-Aerobic Selenium-π-Acid Multicatalysis"

Kilian A. Müller, Carolin H. Nagel, Alexander Breder*, Eur. J. Org. Chem. 2023, 26, e2022011 (invited manuscript)




24. "Hydrogen-Bond-Modulated Nucleofugality of SeIII Species to Enable Photoredox-Catalytic Semipinacol Manifolds"

Sooyoung Park, Amit K. Dutta, Carina Allacher, Anton Abramov, Philipp Dullinger, Katerina Kuzmanoska, Daniela Fritsch, Patrick Hitzfeld, Dominik Horinek, Julia Rehbein*, Patrick Nuernberger*, Ruth M. Gschwind*, Alexander Breder* Angew. Chem. Int. Ed. 2022, e202208611 (accepted manuscript, DOI: 10.1002/anie.202208611)




23.  "Synthesis of Aminoallenes via Selenium-π-Acid-Catalyzed Cross-Coupling of N-Fluorinated sunlfonimides with Simple Alkynes"

Katharina Rode, Poorva Ramadas Narasimhamurthy, Rene Rieger, Felix Krätzschmar, Alexander Breder* Eur. J. Org. Chem. 2021, 1720 – 1725 (invited contribution to the "YourJOC Talents" Special Collection).





22.  "Rational Design of Chiral Selenium-π-Acid Catalysts"

F. Krätzschmar, S. Ortgies, R. Y. N. Willing, A. Breder,* Catalysts 2019, (2), 153.



21. "Light-Driven Single-Electron-Transfer Processes as an Enabling Principle in Sulfur- and Selenium-Multicatalysis"

A. Breder,* C. Depken, Angew. Chem. Int. Ed. 2019, 58, 17130-17147.


20. "Aerobic Allylation of Alcohols with Non-Activated Alkenes Enabled by Light-Driven Selenium-π-Acid Catalysis"

K. Rode, M. Palomba, S. Ortgies, R. Rieger, A. Breder,* Synthesis 2018, 50, 3875. (invited Feature Article)


19. "Mechanistic Studies on the Anodic Functionalization of Alkenes Catalyzed by Diselenides"

M. Wilken, S. Ortgies, A. Breder,* I. Siewert,* ACS Catal. 2018, 8, 10901


18. "Photocatalytic Aerobic Phosphatation of Alkenes"

C. Depken,° F. Krätzschmar,° R. Rieger, K. Rode, A. Breder,*

Angew. Chem. Int. Ed. 2018, 57, 2459.
Angew. Chem. 2018, 130, 2484.
(This manuscript was highlighted in Synfacts 2018, 14, 314)
(° these authors contributed equally to this manuscript)


17. "Mechanistic and Synthetic Investigations on the Dual Selenium-π-Acid/Photoredox Catalysis in the Context of the Aerobic Dehydrogenative Lactonization of Alkenoic Acids"

S. Ortgies, R. Rieger, K. Rode, K. Koszinowski, J. Kind, C. M. Thiele, J. Rehbein, A. Breder,* ACS Catal. 2017, 7, 7578.

16. "Oxidative Alkene Functionalizations via Selenium-π-Acid Catalysis"

S. Ortgies, A. Breder,* ACS Catal. 2017, 7, 5828


15. "Synthesis of (+)-Greek Tobacco Lactone via a Diastereoablative Epoxidation and a Selenium-Catalyzed Oxidative Cyclization"

S. Leisering, I. Riano, C. Depken, L. Gross, M. Weber, D. Lentz, R. Zimmer, C. B. W. Stark,* A. Breder,* M. Christmann,* Org. Lett. 2017, 19, 1478


14. "Oxidative Allylic Esterification of Alkenes by Cooperative Selenium-Catalysis Using Air as the Sole Oxidant"

S. Ortgies, C. Depken, A. Breder,* Org. Lett. 2016, 18, 2856


13.  "Iodine(III)-mediated oxidative intramolecular arene-alkene coupling exemplified in the synthesis of phenanthrenes"

C. Depken, F. Krätzschmar, A. Breder,* Org. Chem. Front. 2016, 3, 314-318 (invited contribution to the themed collection "2015 Emerging Investigators by OCF")


12. "Selenium-Catalyzed Oxidative C(sp2)–H Amination of Alkenes Exemplified in the Expedient Synthesis of (Aza-)Indoles"

S. Ortgies, A. Breder,* Org. Lett. 2015, 17, 2748-2751


11. "Recent developments in sulfur- and selenium-catalyzed oxidative and isohypsic functionalization reactions of alkenes"

A. Breder,* S. Ortgies, Tetrahedron Lett. 2015, 56, 2843-2852 (invited Digest Article)


10. "Selenium-Catalyzed C(sp3)–H Acyloxylation: Application in the Expedient Synthesis of Isobenzofuranones" |Hot Paper|

F. Krätzschmar, M. Kaßel, D. Delony, A. Breder,* Chem. Eur. J. 2015, 21, 7030-7034


9.  "Young Career Focus: Dr. Alexander Breder"

A. Breder,* Synform 2014, 4, Synstories A56


8. "Oxidative Allylic Amination Reactions of Unactivated Olefins – At the Frontiers of Palladium and Selenium Catalysis"

A. Breder,* Synlett 2014, 25, 899-904 (invited Synpacts article)


7. "Direct Oxidative Allylic and Vinylic Amination of Alkenes through Selenium Catalysis"

J. Trenner, C. Depken, T. J. Weber, A. Breder,*
Angew. Chem. Int. Ed. 2013, 52, 8952-8956.

Angew. Chem. 2013, 125, 9121-9125

2008-2012 (Ph.D & Postdoc Work)


6. "Atom-Economical Synthesis of Functionalized Cycloalkanes via Catalytic Redox Cycloisomerization"

B. M. Trost, A. Breder, K. Bao, Org. Lett. 2012, 14, 1708-1711


5. "Towards the Synthesis of Massadine: A Unified Strategy for the Stereoselective Synthesis of the Carbocyclic C,D-Ring Subunit"

A. Breder, G. M. Chinigo, A. W. Waltman, E. M. Carreira, Chem. Eur. J. 2011, 17, 12405-12416


4. "Propargyl Alcohols as β-Oxocarbenoid Precursors for the Ruthenium-catalyzed Cyclopropanation of Unactivated Olefins by Redox Isomerization"

B. M. Trost, A. Breder, B. M. O'Keefe, M. Rao, A. W. Franz, J. Am. Chem. Soc. 2011, 133, 4766-4769


3. "An Atom-Economical Access to β-Heteroarylated Ketones from Propargylic Alcohols via Tandem Ruthenium/Indium-Catalysis"

B. M. Trost, A. Breder, Org. Lett. 2011, 13, 398-401


2. "Ugi-4-Component Reaction Enabling Rapid Access to the Core Fragment of Massadine"

G. M. Chinigo, A. Breder, E. M. Carreira, Org. Lett. 2011, 13, 78–81


1. "Enantioselective Synthesis of the Carbocyclic D-Ring Subunit of Massadine"

A. Breder, G. M. Chinigo, A. W. Waltman, E. M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 8514–8517 (highlighted in CHIMIA 2008, 62, 980)

  1. Fakulty of Chemistry and Pharmacy
  2. Institute of Organic Chemistry

The Breder Group

Prof. Dr.
Alexander Breder



Secretary: CH 23.1.80
Phone: +49 (0)941 943-4626
Fax: +49 (0)941 943-4617

Prof. Breder: CH 13.1.82
Phone: +49 (0)941 943-4802