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Research - Structure Optimization

Structure variations are done based on the activity tests. Especially, the modification of the α,β-unsaturated carbonyl system is in the focus in order to get compounds with better activity and selectivity.

Optimization cycle

The selection of the rests R' and R'' allows for a control on the electronic and steric properties in order to gain activity increase and activity loss. With continuous evaluation of the synthesized derivatives a sustained examination of activity is achieved which will lead to a structural optimization of potential drug candidates.

 

  1. Faculty of Chemistry and Pharmacy
  2. Institute of Organic Chemistry

Research Group Amslinger

Dr.
Sabine Amslinger

 

Office

Building CH, room 32.1.85

Phone ++941 943-4650
Fax ++941 943-4121
E-mail