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Forschung - Strukturoptimierung

Structure variations are done based on the activity tests. Especially, the modification of the α,β-unsaturated carbonyl system is in the focus in order to get compounds with better activity and selectivity.

Optimization cycle

The selection of the rests R' and R'' allows for a control on the electronic and steric properties in order to gain activity increase and activity loss. With continuous evaluation of the synthesized derivatives a sustained examination of activity is achieved which will lead to a structural optimization of potential drug candidates.


  1. Fakultät für Chemie und Pharmazie
  2. Institut für Organische Chemie

Arbeitskreis Amslinger

Sabine Amslinger



Gebäude CH, Zi. 33.1.85

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