Our research profile is based on the development of new catalytic transformations using Brønsted acids and their application in organic synthesis. Our main interrests are:
The attachement of an activating group to alkene enables replacement of traditional metal catalysts by Brønsted acids in the hydrofunctionalization of alkenes. We seek for new reactivity and transformations. We have developed an acid-catalyzed hydroarylation of vinylphenols, which proceeds via stabilized intermediates and allows for the synthesis of a broad range of 1,1-diarylmethanes (RSC Advances 2015, 5, 493).
In the presence of Brønsted acids, various Pd precursors are converted to the catalytically active Palladiumhydride complexes. First, we have reported Pd-catalyzed alkoxycarbonylation of alkenes based on the use of a bidentate ligand and a phosphoric acid, which proceeds under mild reaction conditions (Chem. Commun. 2015, 51, 12574). Notably, a recyclable CO2 reduction product - the crystalline and air-stable N?formylsaccharin - was employed as a CO surrogate. The desired branched products were produced from styrene derivatives and valuable linear esters from alkyl-substituted alkenes.
In addition, the first thiocarbonylation of styrene derivatives was developed (J. Am. Chem. Soc. 2016, 138, 16794). The combination of thiols as nucleophiles and a bidentate ligand led to an exceptional reaction outcome with high regioselectivity towards the more valuable branched isomer and new reactivity.